Add time:08/29/2019         Source:sciencedirect.com

Modern pharmacology is not only interested in the development of new drugs, but also in a revival of older drugs to be vehicolated with opportune chemical shuttles that can modify their pharmacokinetics (and to a lesser extent, the pharmacodynamics). This is particularly important for cytotoxic and chemotherapeutic agents that are burdened by severe side effects due to an unspecific action toward cancerous cells and nonneoplastic cells: in this field, the availability of a good vehicle able of targeting the cancerous cells can make the difference between an effective drug and an ineffective treatment. Similarly, drugs that have an unsatisfactory pharmacokinetic profile (e.g., peptides, nucleic acids) can benefit from drug delivery systems that can make them more effective.For this reason, cycloadditions appears particularly attractive to build up the drug shuttle due to their mild conditions, high yields, and tolerability toward different functional groups.

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