Synthesis of nucleoside-3', 5'-cyclic phosphorothioates by cyclothiophosphorylation of unprotected nucleosides-Science-Chemical Encyclopedia-lookchem

Synthesis of nucleoside-3', 5'-cyclic phosphorothioates by cyclothiophosphorylation of unprotected nucleosides
Add time:09/01/2019 Source:sciencedirect.com

Unprotected nucleosides 1 were thiophosphorylated with thlophosphoryl chloride in trlalkyl phosphates and directly cycllzed by alkali hydroxide in aqueous acetonftrile to give the diaslereomers 3 and 4 of nucleoslde - 3', 5'- cyclic phosphorothioates in good yields.

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