Add time:09/08/2019         Source:sciencedirect.com

N-Phosphoryl amino acids were prepared rapidly and in high yield via phosphoramidite amine-exchange in the presence of 1H-tetrazole followed by oxidation with mCPBA. Formation of dibenzyl phosphoramidates incorporating the representative C-terminal protected amino acids leucine, phenylalanine, glutamic acid, and proline were demonstrated to be most successful with dibenzyl N,N-dimethylphosphoramidite although the N,N-diethyl and N,N-diisopropyl analogs also provided high yields.

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