Encyclopedia

  • Full paperIdentification and functional analysis of choline transporter in tongue cancer: A novel molecular target for tongue cancer therapy
  • Add time:08/30/2019         Source:sciencedirect.com

    We examined the functional characteristics of choline uptake in human tongue carcinoma using the cell line HSC-3. Furthermore, we explored the possible correlation between the inhibition of choline uptake and apoptotic cell death. Both choline transporter-like protein 1 (CTL1) and CTL2 mRNAs and proteins were expressed, and were located in plasma membrane and mitochondria, respectively. Choline uptake was saturable and mediated by a single transport system, which is pH-dependent. Several cationic drugs inhibited cell viability and [3H]choline uptake. Choline uptake inhibitors and choline deficiency inhibited cell viability and increased caspase-3/7 activity. We conclude that extracellular choline is mainly transported via a CTL1 that relies on a directed H+ gradient as a driving force. The functional inhibition of CTL1 by cationic drugs could promote apoptotic cell death. Furthermore, CTL2 may be the major site for the control of choline oxidation in mitochondria and hence for the supply of endogenous betaine and S-adenosyl methionine, which serves as a major methyl donor. Identification of this CTL1- and CTL2-mediated choline transport system provides a potential new target for tongue cancer therapy.

    We also recommend Trading Suppliers and Manufacturers of Choline methionine tartrate (cas 1334-17-4). Pls Click Website Link as below: cas 1334-17-4 suppliers


    Prev:Effect of nitric oxide on the formation of cobalt–aluminum oxide structure from layered double hydroxide and its further transformation during reductive activation
    Next: Basic nutritional investigationLipid peroxidation in mice fed a choline-deficient diet as evaluated by total hydroxyoctadecadienoic acid)

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View