Add time:08/31/2019         Source:sciencedirect.com

Fungal diseases are a menace to human life. They are a major problem, not only for individuals suffering from primary infection, but also for individuals suffering from fungal infection as a secondary infection and for immunocompromised patients suffering from other disorders. Vaginal candidiasis is a major predominant problem in women in addition to corneal, skin, and oral candidiasis. Nanoparticles’ advantages over conventional methods, including deeper tissue penetration, targeted delivery capacity, controlled release, and extended duration, for the treatment of different diseases (Ghosh and Ansar, 2014; Ghosh et al., 2015) are well-known. Nanoparticles’ role in the control of fungal infection has a 30-year history of development, which has increased significantly in recent years, but their toxicity and biocompatibility have limited any large-scale application. On the other hand, green synthesis and the design of nanoparticles from natural resources is a relatively new domain able to minimize nanoparticles’ toxic effects, thus conferring an advantage over other synthesis methods and existing nanoparticle applications in the control of human fungal infections. In this chapter, we discuss the advances in the application of nanoparticles to targeting fungal infections, the improvements of nanoparticle generation via green synthesis, and the latest applications and developments in the control of fungal infections. However, this chapter is limited in its understanding the advances in synthesis of nanoparticles in designing and delivery of antifungals actively under research.

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