Add time:09/01/2019 Source:sciencedirect.com
Light-based approaches to the assessment of a tissue’s oxygen status are attractive to the clinician because they provide the possibility of continuous noninvasive measurements. For example, pulse oximetry, which relies on emission and absorption of light in red and infrared frequencies (660 and 940 nm, respectively), has become widely used in clinical practice. Near-infrared (NIR) spectroscopy technology takes this further and uses light in the near-infrared range (700 to 1000 nm). This chapter reviews the principles of NIR spectroscopy, quantifies physiologic variables, and reports clinically relevant observations that have been made using this technology. Three different methods of using NIR light for monitoring tissue oxygenation that are currently used—(1) continuous wave method, (2) time-of-flight method, and (3) frequency domain method—have been described, along with techniques used to measure oxygen delivery and consumption in cerebral and peripheral tissue.
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