Add time:09/02/2019         Source:sciencedirect.com

An efficient method for the synthesis of a novel series of cyclopenta[b]pyrano pyrimidinone derivatives with silica-bonded N-propyl diethylenetriamine sulfamic acid (SBPDSA) as catalyst has been achieved by the condensation of 2-amino-4-phenyl-5-oxo-4,5,6,7-tetrahydrocyclopenta[b]pyran-3-carbonitrile derivatives and coumarin-3-carboxylic acid under solvent free conditions. Antimicrobial studies showed all the target compounds processing good antibacterial and antifungal activities.

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