Add time:09/01/2019 Source:sciencedirect.com
PHI/M (peptide histidine isoleucine, or its human counterpart peptide histidine methionine) was originally identified as a porcine peptide and presents in large quantities in the intestine. PHI/M has sequence homologies with vasoactive intestinal polypeptide (VIP). PHI/M, VIP, and peptide histidine valine (PHV) are co-synthesized from the same precursor, and have a similar structure and biological functions. PHI/M binds to two VIP receptors, VPAC1-R and VPAC2-R, but with lower binding affinity compared with VIP or PACAP. PHI/M has been reported to increase the release of prolactin, insulin, and glucagon, similarly to VIP and PACAP.
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