Add time:09/03/2019         Source:sciencedirect.com

Over the course of many decades, life sciences have gained an insight into the structure–activity relationship of biologically active molecules, thereby allowing for a deeper understanding of how such molecules can be modified to produce the desired effect within a living organism. The introduction of either a nitrogen-containing heterocycle or a fluorine-containing unit are commonly used strategies in the pharmaceutical and agrochemical industries to fine-tune the activity, toxicity, and metabolic stability, among other properties, of their respective products. Herein, an overview of the latest fluorine containing N-heterocyclic molecules of significant biological importance, either as drugs or agrochemicals, is presented. To limit the scope of this report we have selected molecules in which the fluorine atom or the fluorine-containing unit is directly attached to the N-heterocyclic core.

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