Add time:08/31/2019         Source:sciencedirect.com

cryptosin (cas 111420-57-6) -a new cardenolide was found to be a potent inhibitor of cardiac Na+ and K+ dependent Adenosinetri-phosphatase (7). In experiments with dog heart exvivo, development of inotropic and toxic effect correlated with changes in the cardiac dihydropyridine-specific calcium channels as measured by the binding of 3[H]PN 200-110. A significant change in the PN 200-110 binding was observed when guinea pig and dog heart sarcolemmal membranes were pre-incubated with cryptosin invitro. Binding analysis of 3[H]PN 200-110 (Isradipine) -a 1,4-dihydropyridine analog with very specific calcium channel binding properties — in both invitro and exvivo studies were consistent and indicated a non-specific type of interaction of cryptosin with mammalian cardiac 1,4-dihydropyridine-specific calcium channels.

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