Add time:08/30/2019         Source:sciencedirect.com

Biotransformation of 6α-santonin (1) and 1,2-dihyro-α-santonin (2) by two fungal strains Acremonium chrysogenum (Cephalosporium chrysogenum) and Rhizomucor pusillus has been investigated for the first time. After 8 days of incubation of 1 by A. chrysogenum, four known metabolites including 1,2-dihydro-α-santonin (2) (30%), 8α-hydroxyl-α-santonin (3) (22%), 15-hydroxy-α-santonin (4) (15%) and 4,5-dihydro-α-santonin (5) (10%) were obtained. Incubation of 1 by R. pusillus afforded two metabolites 2 (45%) and 3 (20%). Biotransformation of 1,2-dihyro-α-santonin by A. chrysogenum produced tetrahydro-α-santonin (6) with 52% yield and tetrahydroartemisin (7) with 33% yield. By R. pusillus, the yields of 6 and 7 were 32% and 21%, respectively. The structures of the products were identified on the basis of spectroscopic data.

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