Add time:08/31/2019         Source:sciencedirect.com

How and why the chemical stability of amorphous solid is different from crystalline solid is an important problem. In this study, this problem is addressed by evaluation of the photodegradation of both crystalline and amorphous MK‐912 (an α‐2 adrenoceptor antagonist) according to the photostability tests of the ICH (International Conference on Harmonization) guidelines. Under the ICH conditions, the photodegradation rate of the amorphous MK‐912 was ∼40 times faster than that of the crystalline MK‐912. The photodegradation yielded isomeric, oxidative degradates. Three keto‐degradates (molecular weight of 14 Da over MK‐912) were observed for both forms. But, whereas five alcohol and one N‐oxide degradates (molecular weight of 16 Da over MK‐912) were observed for the amorphous form, only one alcohol degradate was observed for the crystalline form. Liquid chromatography/mass spectrometry (LC/MS) and LC/MS/MS were applied to identify these low‐level photodegradates. A thorough analysis of the MS/MS data of protonated MK‐912 was the key to the identification, and the special MS/MS features of the degradates due to the structural modifications from degradations were also important. Following this strategy, the structures of all the photodegradates were proposed. The structural identification of the photodegradates of MK‐912 shed light on the different photostabilities between the crystalline and amorphous MK‐912. © 2001 Wiley‐Liss, Inc. and the American Pharmaceutical Association J Pharm Sci 90:833–844, 2001

We also recommend Trading Suppliers and Manufacturers of MK-912 (cas 111466-41-2). Pls Click Website Link as below: cas 111466-41-2 suppliers