Add time:09/01/2019         Source:sciencedirect.com

A convenient route to optically active pyrazolidine derivatives from Pd(0)/(R,R)-Bn-BOX-catalyzed enantioselective cyclization of 3,4-allenylic hydrazines in the presence of organic halides has been developed, the ee value is 75–84%. The absolute configuration of the products was determined by the conversion of one of the products to a known product prepared in this group. The reaction may proceed via the oxidative addition, intermolecular carbometallation of the allene moiety forming a π-allylic palladium intermediate, and the intramolecular enantioselective allylation.

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