Add time:09/01/2019         Source:sciencedirect.com

The utility and usefulness of isocoumarin framework has been explored in different areas including medicinal/pharmaceutical chemistry, drug discovery, and organic synthesis. For example, compounds based on isocoumarin scaffold have been evaluated as PDE4 and various enzyme inhibitors, 5-LOX inhibitors, potential anticancer agents, antibacterial/antifungal agents, etc. Similarly, isocoumarin-based compounds have been used as a precursor of NM-3, nitidine, (+)-sescandelin, 5-AIQ analogs, fused heterocycles, Sparstolonin B, polyheterocyclic compounds, etc. Details of these are presented in the chapter.

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