Add time:09/03/2019         Source:sciencedirect.com

A more efficient preparation of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile (2), the penultimate intermediate in the synthesis of bosutinib (1a), was developed. New 7-alkoxy-4-phenylamino-3-quinolinecarbonitrile Src inhibitors were prepared from 5 and 9, the 6-ethoxy and 6-hydrogen analogs of 2. In addition, the fluoro group of 2 was readily displaced by primary and secondary amines to give 7-amino analogs. Two of these 7-amino analogs, 15 and 18, were potent Src inhibitors with in vivo activity.

We also recommend Trading Suppliers and Manufacturers of 2-[(4-ETHOXY-PHENYLAMINO)-METHYL]-PHENOL (cas 104768-31-2). Pls Click Website Link as below: cas 104768-31-2 suppliers