Add time:09/01/2019         Source:sciencedirect.com

The mode of action for endomycin-neomycin synergism against Candida albicans was postulated to be an action of endomycin which influences permeability of the cell membrane and facilitates the entry of neomycin in the cell. A neomycin-resistant strain was also found to be resistant to endomycin, but the combination of antibiotics was still synergistic. The permeability hypothesis of endomycin was strengthened by data showing that the cell membrane barrier was less resistant to increasing osmotic pressure in the presence of endomycin.

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