Add time:09/06/2019 Source:sciencedirect.com
Syntheses of dehydroalanine derivatives via a solid-support route, starting from selenocystein, and via conventional solution phase chemistry are described along with initial biological testing. The target compounds were designed as mimetics of the dehydroalanine side chain of the macrocyclic antibiotic THIOSTREPTON (cas 1393-48-2) that acts on the bacterial ribosome.
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