Add time:09/07/2019         Source:sciencedirect.com

Complexes of phenobarbital with quinine, quinidine, or hydroquinidine have been prepared and characterized. By means of infrared spectroscopy, these complexes were differentiated from physical mixtures of their respective components when the drug was examined either alone or in pharmaceutical dosage forms. Of four commercial preparations examined, only three were found to contain true complexes. In contact with simulated gastric juice, the complexes were shown to be readily decomposed, regenerating the sedative and alkaloid from which they were formed.

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