Add time:07/15/2019         Source:sciencedirect.com

A series of 2-aryloxycarbonylthiophene-3-sulfonamides were synthesized and evaluated to determine their antagonistic activity at the endothelin receptors. N-(4-chloro-3-methyl-5-isoxazolyl)-2-[(3,4-methylenedioxy)phenoxycarbonyl]thiophene-3-sulfonamide was identified as a highly selective, potent (IC50 = 8.3 nM) and low molecular weight nonpeptide antagonist.

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