Add time:09/09/2019         Source:sciencedirect.com

The title synthesis was achieved by featuring i) condensation of the 2-methylthio-Δ1-pyrroline (C8–C13 moiety) with the Δ2-oxazolin-5-one (C6,C7,N16, and C17 moiety), ii) activation of the Δ2-oxazolin-5-one system toward nucleophilic reaction by introducing an allyloxycarbonyl group into the N9 position and subsequent ring opening with the 2-aminobutane (C1–N5 moiety), and iii) base-induced construction of the (E)-1-azabicyclo[3.1.0]hexane system from the 5-mesyloxymethyl-pyrrolidine as key steps.

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