Add time:09/09/2019 Source:sciencedirect.com
No information is available on the structural requirements for the antitumor activity of SPARSOMYCIN (cas 1404-64-4), an antibiotic obtained from the fermentation broth of Streptomyces sparsogenes. Its high in vivo and in vitro activity, novel structure, and uncommon mode of action have, therefore, suggested the synthesis of analogs. This report describes the preparation and screening of a series of N-substituted 3-aryl acrylamides which are closely related to sparsomycin. Three compounds exhibited some tumor inhibition but insufficient to warrant further testing.
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