Add time:07/17/2019         Source:sciencedirect.com

In this paper, we have described the conventional and microwave methods for the synthesis of 1-[2-(2-chloro-6-methyl(3-quinolyl))-5-(4-nitrophenyl)(1,3,4-oxadiazolin-3-yl)]-3-(aryl)prop-2-en-1-ones (4a–l). Through this method, we have observed a decrease in reaction time and a better yield than the previously described conventional method. The application of microwave irradiation (MWI) is used for carrying out chemical transformations which were pollution free and eco-friendly. The structures of the compounds were characterized by IR, NMR and mass spectral data. These compounds (4a–l) were evaluated for their in vitro antimicrobial screening on different strains of bacteria and fungi. Among the compounds tested, compound 4h showed the highest activity.

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