Add time:09/05/2019         Source:sciencedirect.com

Catabolite repression collectively describes the reversible process by which during rapid catabolism of one carbon source, uptake and catabolism of poorer substrates is prevented. The common logic of the global sensory and regulatory mechanisms involved, with a central role for protein kinases/phosphatases, targeting subunits, and global gene regulators, is illustrated using two examples from eubacteria, and one from the eukaryotic yeast. At the beginning of catabolite repression, uptake and catabolism of poorer substrates are inhibited collectively in an immediate response (inducer exclusion). This is followed by a delayed response through global gene regulators that control directly transcription of the genes involved in carbon catabolism and energy production (carbon catabolite repression), and indirectly cell motility, carbon storage, cell-surface changes, virulence, and cell division.

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