Add time:09/01/2019         Source:sciencedirect.com

Novel α-fluoroalkoxyacetophenones were synthesized by addition of the readily available 2,2-dimethoxy-2-phenylethanol to fluoroolefins. α-Bromination yielded α-bromo-α-fluoroalkoxyacetophenones, which on treatment with thioureas or thioamides gave thiazoles with fluoroalkoxy groups at the 5′-position by the Hantzsch-type cyclization. This provides a versatile methodology for the construction of heterocycles from aliphatic fluoroalkoxy containing building blocks.

We also recommend Trading Suppliers and Manufacturers of 5-bromo-4-trifluoromethyl-thiazole-2-ylamine (cas 136411-21-7). Pls Click Website Link as below: cas 136411-21-7 suppliers