Add time:09/04/2019         Source:sciencedirect.com

The long-lasting sympathomimetic effects of oxyfedrine on the rat perfused heart, rat uterus and guinea-pig trachealis can be prevented or terminated by propranolol. Reserpine pretreatment did not affect the early peak cardiac responses or the responses of the other two tissues but abolished the late phase of its cardiac action. Oxyfedrine caused partial depletion of cardiac noradrenaline. A high concentration was needed to affect the uptake of 3H-noradrenaline by the rat uterus. 14C-oxyfedrine was taken up by tissues — this uptake was unaffected by cocaine, desipramine, metanephrine or phenoxybenzamine; it was reduced by cooling and increased by reserpine pretreatment. The chloroform-aqueous phase partition of oxyfedrine indicated high lipid solubility and its tissue uptake was attributed to this property. In the rat uterus the slow efflux of active drug molecules could account for its long duration of action.

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