Add time:09/03/2019         Source:sciencedirect.com

Publisher SummaryThis chapter describes the evaluation of sometribove in toxicology and clinical trials in Europe and the United States. Somatotropin purified from bovine pituitary glands consistently increases milk yields when administered to lactating dairy cows. High doses of sometribove were administered to dairy cows to assess both the safety and margin for error in dosing of sometribove. In the most extreme experiment, cows were administered two doses of 15 g of sometribove at a one week interval. This represented a lifetime amount of sometribove at the commercial dose of 500 mg in one week. During the first weeks of sometribove administration, milk yields are increased immediately and the increase in voluntary feed intake lags behind the requirements for milk synthesis. Cows respond by increasing adipose mobilization reflected in increased plasma nonesterified fatty acids (NEFAs) and sparing protein catabolism, which results in lower concentrations of blood urea N and creatinine in the sometribove groups. There was no evidence of subclinical ketosis and both short and long term betahydroxybutyrate concentrations were not different from controls.

We also recommend Trading Suppliers and Manufacturers of somatotropin fragment 96-133 (cas 111524-50-6). Pls Click Website Link as below: cas 111524-50-6 suppliers