Add time:07/14/2019         Source:sciencedirect.com

We have developed a practical enantioselective synthesis of 1, a novel indane acetic acid derivative with two contiguous stereogenic centers. The key indene acetic acid framework was constructed via a robust, unprecedented Reformatsky process. One stereogenic center was set via a resolution, and the other via a highly diastereoselective hydrogenation of the indene acetic acid.

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