Add time:09/02/2019 Source:sciencedirect.com
A series of novel nicotinohydrazide derivatives 6a–g and 1,3,4-oxadiazole functionalized pyridine derivatives 7a–k and 8a–d were prepared in series of steps. All the compounds were screened for cytotoxicity against HeLa (cervical), DU145 (prostate), HepG2 (liver) and MBA-MB-231 (breast) human cancer cell lines. Compounds 6h, 6i, 7d, 7h, 7i and 8b which showed promising cytotoxicity at <15 μM concentration have been identified. Further optimization of the structure is underway to identify a lead compound.
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