Add time:09/03/2019         Source:sciencedirect.com

The maternal transfer and developmental toxicity of chiral contaminants with respect to enantioselectivity have rarely been investigated. Here, the residues and toxicological responses of cis-BF, a typical chiral pesticide, were studied in the progeny of adult zebrafish exposed to cis-BF (0, 20, 100, and 500 ng/L) for 60 days. Cis-BF enantiomers exhibited the equal maternal transfer potentials. GC/MSD analysis showed that parental 1S-cis-BF exposure could disrupt the components of fatty acids in offspring embryos. In transcriptional expression, the whole differentially expressed genes were significantly enriched in GO categories, including the processes related to lipid biosynthesis/metabolism. The perturbations of fatty acids suggested that cis-BF has potential negative impacts on embryos’ development. Furthermore, enantioselective growth inhibition and developmental neurotoxicity in larvae were also observed. The mRNA expressions of neuronal development genes were significantly changed in 1S-exposed offspring, so were the levels of the neurotransmitters and larval locomotion. Our results show that the cis-BF induced the growth inhibition and neurotoxicity in zebrafish larvae, which may be mediated by the development interference in embryos related to the disrupted fatty acid composition. Furthermore, the toxicological response to 1S-cis-BF was greater than that to the 1R-enantiomer in the offspring of exposed adults.

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