Add time:09/02/2019         Source:sciencedirect.com

A toxicologic and dermatologic review of 1,1-dimethyl-2-phenylethyl acetate when used as a fragrance ingredient is presented. 1,1-Dimethyl-2-phenylethyl acetate is a member of the fragrance structural group Aryl Alkyl Alcohol Simple Acid Esters (AAASAE). The AAASAE fragrance ingredients are prepared by reacting an Aryl Alkyl Alcohol with a simple carboxylic acid (a chain of 1–4 carbons) to generate formate, acetate, propionate, butyrate, isobutyrate and carbonate esters. This review contains a detailed summary of all available toxicology and dermatology papers that are related to 1,1-dimethyl-2-phenylethyl acetate and is not intended as a stand-alone document. Available data were evaluated, then summarized, and includes: physical properties; acute toxicity; skin irritation; mucous membrane (eye) irritation; skin sensitization; elicitation; and toxicokinetics data. A safety assessment of the entire AAASAE will be published simultaneously with this document. Please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all AAASAE in fragrances.Belsito, D., Bickers, D., Bruze, M., Calow, P., Dagli, M., Fryer, A.D., Greim, H., Hanifin, J.H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2012. A toxicologic and dermatologic assessment of Aryl Alkyl Alcohol simple acid esters when used as fragrance ingredients.

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