TBN as a metal-free reagent initiated sp3 C–H functionalization of glycine esters: Synthesis of quinoline-2-carboxylate esters-Science-Chemical Encyclopedia-lookchem

TBN as a metal-free reagent initiated sp3 C–H functionalization of glycine esters: Synthesis of quinoline-2-carboxylate esters
Add time:09/02/2019 Source:sciencedirect.com

As a metal-free reagent, tert-butylnitrite (TBN) initiated aerobic sp3 C–H bond oxidation of glycine esters was achieved, providing a series of quinoline-2-carboxylates in good yields. The mechanistic investigation revealed that in the presence of molecular oxygen, TBN derived radicals were involved in the C–H bond oxidation and the terminal aromatization.

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