Coupling of 6-chloropurines with organocuprates derived from grignard reagents: A convenient route to sec and tert 6-alkylpurines-Science-Chemical Encyclopedia-lookchem

Coupling of 6-chloropurines with organocuprates derived from grignard reagents: A convenient route to sec and tert 6-alkylpurines
Add time:09/05/2019 Source:sciencedirect.com

Purine derivatives bearing a secondary or tertiary alkyl group at the 6-position can be conveniently prepared by CuI mediated reaction of secondary or tertiary Grignard reagents with 9-substituted 6-chloropurines under very mild conditions.

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