Add time:09/03/2019 Source:sciencedirect.com
Poly (n-butyl cyanoacrylate) (PBCA) nanoparticles are widely used as biocompatible and bio-erosive materials in a range of biomedical applications, especially for drug delivery systems. This paper reports a novel synthesis method of PBCA nanoparticles with high productivities and purities in a rotating packed bed. The particle size and molecular weight of PBCA nanoparticles were controlled by adjusting the high-gravity factor, surfactant concentration, pH, temperature and monomer concentration. The high-gravity factor shows an obvious influence on the particle sizes, while it has few effects on molecular weight. The surfactant concentration and pH also affect molecular weight and particle sizes. Moreover, compared with conventional stirred tank, the reaction time of RPB procedure was dramatically reduced from 12 h to 2 h, and the purity of products increased from about 93 % to 96 %. Furthermore, when the molecular weight of PBCA increased, the in vitro cytotoxicity to Hep G2 cells firstly increased and then decreased, and the cellular uptake was improved. In summary, PBCA with controllable molecular weight and particle sizes can be synthesized using a facile high-gravity method.
We also recommend Trading Suppliers and Manufacturers of butyl (Z)-docos-13-enoate (cas 19773-46-7). Pls Click Website Link as below: cas 19773-46-7 suppliers
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View