Add time:09/05/2019 Source:sciencedirect.com
Two optimized and validated spectrophotometric methods have been developed for the determination of Amiodarone hydrochloride (cas 19774-82-4) in commercial dosage forms. Method A is based on the reaction of tertiary amino group of the drug with N-bromosuccinimide in methanol–acetone medium resulting in the formation of a yellow colored product, which absorbed maximally at 353 nm. Method B involves the formation of a colored chloroform extractable ion-pair complex of the drug with bromothymol blue at pH 2.32 absorbing maximally at 400 nm. Beer’s law is obeyed in the concentration ranges 50–600 and 2–55 μg mL−1 with molar absorptivity of 1.58 × 102 and 1.50 × 104 L mol−1 cm−1 for methods A and B, respectively. The regression analysis yields the calibration equations: A = 4.012 × 10−4 + 1.16 × 10−3 C and A = 9.612 × 10−4 + 2.198 × 10−2 C for methods A and B, respectively. The application of the proposed methods to commercial dosage forms is presented.
We also recommend Trading Suppliers and Manufacturers of Amiodarone hydrochloride (cas 19774-82-4). Pls Click Website Link as below: cas 19774-82-4 suppliers
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View