Add time:09/03/2019         Source:sciencedirect.com

The effect of castrix (2-chloro-4-dimethylamino-6-methylpyrimidine) on the distribution of B6 vitamers in mouse brain was determined. The levels of pyridoxal and pyridoxal phosphate decreased, and the levels of pyridoxamine and pyridoxamine phosphate increased at the time of occurrence of convulsions. The decrease in pyridoxal phosphate was almost equal to the increase in pyridoxamine phosphate. A similar effect of castrix was observed in the preconvulsive period of 10 min before the expected onset of convulsions. 4-Deoxypyridoxine, toxopyrimidine, semicarbazide, isonicotinic acid hydrazide or aminooxyacetic acid, at subconvulsant doses, had an anticonvulsant action against the convulsions induced by castrix and prevented the increase in pyridoxamine phosphate produced by castrix, while thiosemicarbazide or penicillamine which did not have an anticonvulsant action did not prevent the increase in pyridoxamine phosphate produced by castrix. These results suggest that convulsions induced by castrix probably occur as a result of the inhibition of synthesis of pyridoxal phosphate from pyridoxamine phosphate.

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