Add time:09/06/2019 Source:sciencedirect.com
SummaryEthers of 1-(2,4-dichlorophenyl)-2-(1-H-imidazolyl)ethanol bearing ramified and/or unsaturated chains have been synthesized in order to specify the role of lipophilicity or steric contributions on antifungal activity against yeast for miconazole-like structures. The presence of ramifications on aliphatic chains (between 4 and 7 carbons) or unsaturation at the end, increases antifungal activity. For these compounds, lipophilicity seems to be counterbalanced by steric contributions.
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