Add time:09/04/2019 Source:sciencedirect.com
Several types of furanomycin (cas 18455-25-9) analogues were synthesized and investigated with respect to their antibacterial activity. Two different synthetic pathways were developed, based on aldol reactions/ring closing metathesis and an ester enolate Claisen rearrangement. Only the natural product and its desmethyl derivative showed antibacterial activity, pointing towards a narrow structure–activity relationship.
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