Add time:09/06/2019         Source:sciencedirect.com

Publisher SummaryThis chapter discusses the cobalt-catalyzed synthesis of pyridine and its derivatives. Pyridine and its derivatives are technically-important fine chemicals. The applications of cobalt-catalyzed pyridine synthesis are briefly discussed. The cobalt-catalyzed pyridine synthesis is the only known one-step process for the selective preparation of the industrially significant 2-substituted-pyridine derivatives. Moreover, the method is applicable to a broad variety of substituted alkynes and nitriles, thereby giving access to a whole range of pyridine derivatives having 1, 2, 3, or 5 substituents in the ring. Selected examples follow and are compared to the prior state of the art. The most interesting application from the industrial point of view is the cobalt-catalyzed one-step synthesis of 2-vinylpyridine. The chapter discusses the experimental technique for the synthesis of pyridines. The batchwise synthesis of pyridines from nitriles and acetylene makes use of acetylene pressures of up to 6.9 MPa. A comparison of a series of [YCo(cod)] catalysts in the test reaction under identical conditions in the continuous-flow apparatus has revealed that the reaction temperature required for 65% propyne conversion depends on the nature of the controlling ligand Y. The structure-activity relationship for cobalt catalysts in the pyridine synthesis is summarized in the chapter.

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