Add time:09/05/2019         Source:sciencedirect.com

The rate of decomposition of aqueous solutions of 5-phosphoribosyl-α-1-pyrophosphate (PRPP) is greatly enhanced by the presence of certain divalent ions. High levels of Mg2+ were shown to increase the rate of phosphate removal from PRPP by factors greater than 100-fold. The combined action of Mg2+ and a nitrogenous compound (imidazole was employed in this study) increases the degradation rate constants by up to 1000-fold. The degradation of PRPP in neutral solutions follows two main paths, a pyrophosphate hydrolysis reaction yielding ribose 5-phosphate and an internal β-phosphate cleavage yielding 5-phosphoribosyl-1,2 cyclic phosphate. The catalytic effect of Mg2+ on PRPP degradation appears to suggest a connection between the observed rate enhancements and the dimagnesium form of PRPP. Rate enhancing effects of Mg2+ are greatest at pH values (i.e. pH>7) which promote strong phosphate–Mg2+ interaction.

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