Add time:09/03/2019 Source:sciencedirect.com
The discovery of the CNS-penetrant and selective α2C adrenergic receptor antagonist N-{2-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1,4]diazepan-1-yl]-ethyl}-2-phenoxy-nicotinamide, 13 is described. Structure–activity studies demonstrate the structural requirements for binding affinity, functional activity, and selectivity over other α2-AR subtypes.
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