Add time:09/09/2019         Source:sciencedirect.com

The total concentration of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethyl glycol (MOPEG) and propranolol concentration was measured in the medulla, pons, hypothalamus and thoracic spinal cord of conscious spontaneously hypertensive rats during the development of the antihypertensive effect of a single dose of d,1-propranolol (10 mg/kg s.c.). Propranolol significantly increased MOPEG concentration by 21% in the thoracic spinal cord (2 h) and 16% in the hypothalamus (4 h), but no consistent pattern of change in regional MOPEG concentration was found in relation to the time course of the antihypertensive effect of propranolol.

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