Add time:09/07/2019         Source:sciencedirect.com

The three Pim kinases are a small family of serine/threonine kinases regulating several signaling pathways that are fundamental to tumorigenesis. As such, the Pim kinases are a very attractive target for pharmacological inhibition in cancer therapy. Herein, we describe our efforts toward the development of a potent, pan-Pim inhibitor. The synthesis and hit-to-lead SAR development from a 3-(pyrazin-2-yl)-1H-indazole derived hit 2 to the identification of a series of potent, pan-Pim inhibitors such as 13o are described.

We also recommend Trading Suppliers and Manufacturers of 3-(pyrazin-2-yl)-1,2,4-thiadiazol-5-amine (cas 138588-23-5). Pls Click Website Link as below: cas 138588-23-5 suppliers