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  • Short communicationGreen synthesis and characterization of supported gold nanoparticles ([email protected]) from Schisandra chinensis fruit extract: An efficient and reusable catalyst for the synthesis of chromeno[2,3-d]pyrimidin-2-yl)phenol derivatives under solvent-free conditions
  • Add time:09/05/2019         Source:sciencedirect.com

    We have demonstrated a simple, green, and environmentally friendly approach for the synthesis of polystyrene-supported gold ([email protected]) nanoparticles by using Schisandra chinensis fruit extract through a novel chemical route. The prepared [email protected] NPs have been well characterized by UV–visible, SEM, TEM, XRD, DLS, and EDX studies. Further, the obtained [email protected] NPs were used as an effective and reusable heterogeneous catalyst for the synthesis of chromeno[2,3-d]pyrimidin-2-yl)phenol derivatives by one-pot pseudo four-component reaction of 2-hydroxybenzaldehydes, secondary amines, and malononitrile under solvent-free reaction conditions. The notable features of this “green” reaction are good to excellent yields, shorter reaction times, avoidance of toxic solvents, gram-scale synthesis, and substrate diversity. The main advantages of [email protected] NPs are its catalytic activity, easy recovery, and reusability for five consecutive runs without any apparent loss in its catalytic activity.

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    Next: 3D-QSAR, molecular docking and molecular dynamics simulations study of 3-pyrimidin-4-yl-oxazolidin-2-one derivatives to explore the structure requirements of mutant IDH1 inhibitors)

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