Add time:09/08/2019         Source:sciencedirect.com

New [5]ferrocenophane based diphosphine ligands, having planar and central chirality, were prepared. The stereogenic center was generated by the enantioselective CBS-reduction of [5]ferrocenophan-1-one. The straightforward transformation of hydroxyl group to dimethylamino group afforded amine 7, which was diastereoselectively ortho-lithiated and reacted with ClPPh2 to introduce planar chirality. The structure of the diphosphine 1 was elucidated by X-ray crystallography. The ligand was successfully applied to Pd-catalyzed allylic alkylation (91% ee).

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