Add time:09/06/2019 Source:sciencedirect.com
(S)-(−)-Tetrahydropalmatine 2 and (S)-(−)-canadine 4 were synthesized in three steps from (S)-6, in 33% and 34% overall yield, respectively. Thus, condensation of the (S)-(E)-sulfinylimines 10 and 11 with the carbanion derived from (S)-6 gave the tetrahydroisoquinolines 12 and 13, respectively, which upon TFA induced N-desulfinylation, and subsequent microwave assisted Pictet–Spengler cyclization effected both cyclization and C-desulfinylation producing (S)-(−)-tetrahydropalmatine 2 and (S)-(−)-canadine 4 in optically pure form.
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