Add time:09/04/2019 Source:sciencedirect.com
Optically pure (R)-(1-naphthylmethyl)succinic acid could be efficiently prepared by a combination of optical resolution and racemization of the undesired enantiomer or by catalytic asymmetric reduction of (1-naphthylmethylene)succinic acid over a rhodium (I)-chiral phosphine complex. Highly chemoselective amide formation of di-4-nitrophenyl (R)-(1-naphthylmethyl)succinate with morpholine followed by coupling with methyl (S)-histidinate readily produced the title key synthetic intermediate.
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