Add time:07/14/2019         Source:sciencedirect.com

This study deals with the synthesis of tert-O-alkyl thiohydroxamates and their use as tert-alkoxyl radical precursors. tert-Alkoxyl radicals were applied in mechanistic studies to determine rate constants of (i) p-chlorocumyloxyl radical addition to bicyclo[2.2.1]heptene (k=1×107 M−1 s−1), (ii) 2-phenylhex-5-en-2-oxyl radical 5-exo-trig-cyclization (kcis=3×109 s−1, ktrans=1×109 s−1), and (iii) 2-methyl-5-phenylpent-2-oxyl to 2-hydroxy-2-methyl-5-phenylpent-5-yl radical isomerization (1,5-H-atom shift; k=0.4–1.5×108 s−1). The reactions pose key steps in synthesis of 2,2,5-substituted tetrahydrofurans and 2-bromo-3-alkoxybicyclo[2.2.1]heptanes. Stereoselectivity in 5-exo-trig cyclization (2,5-cis) and intermolecular addition (exo/endo>99:1), originates from torsional strain in transition structures of alkoxyl radical reactions.

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