Add time:09/06/2019         Source:sciencedirect.com

Nanotechnology has recently attracted growing interest in the encapsulation of botanical insecticides for sustainable pest control. Biocompatible, biodegradable, and stimuli-responsive devices, however, were scarcely reported in the field of intelligent formulations of botanical insecticides. In the present study, a temperature-responsive mixed micelle (MMs–Pys–7) was developed for controlled release of pyrethrins by cooperative assembly of poly[2-(2-Methoxyethoxy) ethyl methacrylate-co-Octadecyl methacrylate] (P(MEO2MA94–co–ODA6)), monomethoxy (polyethylene glycol)13-poly(D, L-Lactide-co-glycolide) (mPEG13–b–PLGA5–3) and monomethoxy (polyethylene glycol)45-poly(D, L-Lactide) (mPEG45–b–PLA28) in water. This nanodevice could protect the encapsulated pyrethrins from ultraviolet degradation at 26 °C effectively. It also underwent a phase transition process in water from solution state to turbid state with temperature rising from 13 to 26 °C. By inducing this structural change, MMs–Pys–7 could regulate the pyrethrin release amounts to adapt to the larval mosquito population variations along with the ambient temperature changes. Therefore, MMs–Pys–7 exhibited a higher larvicidal activity against Culex pipiens pallens at 26 °C than that at 14 °C or 18 °C. Compared with a commercial pyrethrin formulation (EW–Pys), MMs–Pys–7 was more toxic to C. p. pallens larvae at 26 °C after 24-h exposure but less toxic at 14 °C. Moreover, MMs–Pys–7 also exhibited a longer-lasting larvicidal activity under natural conditions as compared to EW–Pys. These results suggest that MMs–Pys–7 has great potential to be developed as an intelligent nano-insecticide for mosquito control and that the controlled release mode established in this study can be applied to develop more smart formulations of botanical insecticides of application potential.

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