[18F]FBAU 3′,5′-dibenzoate, a lipophilic prodrug, enhances brain uptake of the cell proliferation tracer [18F]FBAU-Science-Chemical Encyclopedia-lookchem

[18F]FBAU 3′,5′-dibenzoate, a lipophilic prodrug, enhances brain uptake of the cell proliferation tracer [18F]FBAU
Add time:07/20/2019 Source:sciencedirect.com

Introduction1-(2-deoxy-2-[18F]fluoro-β-d-arabinofuranosyl)-5-bromouracil ([18F]FBAU) is a cell proliferation tracer. However, it does not pass readily through the blood-brain barrier. We synthesized a lipophilic prodrug of [18F]FBAU that was intended to enhance brain uptake of [18F]FBAU to improve the imaging of brain cell proliferation.

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