Add time:09/05/2019         Source:sciencedirect.com

A study is described in which diets containing 500 and 1000 ppm of carbarsone (p-ureidobenzene-arsonic acid) were fed to large groups of rats for 104 weeks, and 2000 ppm for 72 weeks followed by a 32-week withdrawal period. The lower dosages caused no changes in growth or efficiency of food utilization, and no deviation from normal hematologic, blood chemical, and urine parameters, or in tissue morphology. The 2000-ppm dose depressed growth and caused marked intestinal inflammatory reactions with the sequelae eventually resulting in death. When this highest dose was withdrawn from the diet of surviving rats at 72 weeks, they recovered completely. There were no indications of a carcinogenic potential of this compound at any dosage. Acute experiments in dogs given carbarsone in massive intragastric doses showed that two-thirds of the urinary arsenic excretion was in the form of arsanilic acid and one-third as the original compound.

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